Traditional: diabetes, weight loss, dyslipidaemia
gastric ulcer, constipation, arthritis, gout

Gymnema
(Gymnema sylvestre)

Gymnema sylvestre extract
with 25% gymnemic acids

Code BOS240 -- Price: $7.50
60 Capsules x 500 mg.

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Summarized Description: Gymnema -- is a "traditional ayurvedic." Also called "gurmar" in Hindi (meaning "destroyer of sugar"), it has been used for thousands of years in the treatment of diabetes and other blood sugar maladies. It not only reduces sugar cravings but blocks the intestinal absorption of glucose, thus making it helpful as a weight loss aid.
Its contribution to an overall conscientious weight loss program is aided by the fact that it also cuts the amount of carbohydrates stored in fat stores, increases the carbs burned for energy, reducing fat stores and increasing energy levels. Because of its mild diuretic effect, a resulting reduction in water retention also helps with weight loss.
Other common uses include constipation, stomachache, liver disorders, gastric ulcers, gout, and rheumatoid arthritis.

Uses & Protocols

Contraindications

Medicinal Activities

Indications

References

• Baskaran, K., et al. "Antidiabetic effect on a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients." J Ethnopharmacol. 1990 Oct;30(3):295-300.
• Brala, PM and Hagan, RL. "Effects of sweetness perception and caloric value of preload on short term intake." Physiol Behav. 1983 Jan;30(1):1-9.
• Int J Crude Drug Res, 86:24[Dec]: 171-176.
• Kurihara Y. "Characteristics of antisweet substances, sweet proteins, and sweetness-inducing proteins." Crit Rev Food Sci Nutr. 1992;32(3):231-52.
• Luo, H, et al. "Decreased bodyweight without rebound and regulated lipoprotein metabolism by gymnemate in genetic multifactor syndrome." Mol Cell Biochem. 2007:299(1-2):93-8.
• Sahu, N, et al. "Triterpenoid Saponins from Gymnema sylvestre." Phytochem. 1996;41:1181-85.
• Zarelli, A., et. al. " History of gymnemic acid, a molecule that does not exist." Nat Prod Commun. 2014 Oct;9(10):1429-32. (Note: Gymnemic acids are a "very complex mixture of dozens of substances.")
• Other specifics taken from select PubMed studies -- see right column.

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Recent Studies on Gymnema
Sourced from PubMed

Disclaimer: The following citations provide findings on the properties of Gymnema and offer insights into prospective areas of future research. These findings should not be inferred to provide the basis of medicinal claims, nor should they be relied upon by the public, as such. Readers who want full access to the PubMed database are encouraged to register with NCBI.
As of Dec., 2017, there were 267 citations posted on Gymnema. Below we list a few of the more notable:

• A systematic review of Gymnema sylvestre in obesity and diabetes management. (2014) Several components extracted from Gymnema prevent the accumulation of triglycerides in muscle and liver, and also decrease fatty acid accumulation in the circulation. In this paper, an attempt has been made to review the effects of various extracts from Gymnema sylvestre in the regulation of carbohydrate and lipid metabolism in both animal and clinical studies.
• Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. (2014) Abstract: "Gymnema sylvestre (Asclepiadaceae), popularly known as "gurmar" for its distinct property as sugar destroyer, is a reputed herb in the Ayurvedic system of medicine. The phytoconstituents responsible for sweet suppression activity includes triterpene saponins known as gymnemic acids, gymnemasaponins, and a polypeptide, gurmarin. The herb exhibits a broad range of therapeutic effects as an effective natural remedy for diabetes, besides being used for arthritis, diuretic, anemia, osteoporosis, hypercholesterolemia, cardiopathy, asthma, constipation, microbial infections, indigestion, and anti-inflammatory. G. sylvestre has good prospects in the treatment of diabetes as it shows positive effects on blood sugar homeostasis, controls sugar cravings, and promotes regeneration of pancreas. The herbal extract is used in dietary supplements since it reduces body weight, blood cholesterol, and triglyceride levels and holds great prospects in dietary as well as pharmacological applications. This review explores the transition of a traditional therapeutic to a modern contemporary medication with an overview of phytochemistry and pharmacological activities of the herb and its phytoconstituents."
• Gymnema sylvestre R. Br., an Indian medicinal herb: traditional uses, chemical composition, and biological activity. (2015)
• Potential anticancer properties of bioactive compounds of Gymnema sylvestre and its biofunctionalized silver nanoparticles. (2014) Conclusion: "Our results show that the anticancer properties of the bioactive compounds of G. sylvestre can be enhanced through biofunctionalizing the SNPs using the bioactive compounds present in the plant extract without compromising their medicinal properties."
• Inhibitory Effects of Gymnema (Gymnema sylvestre) Leaves on Tumour Promotion in Two-Stage Mouse Skin Carcinogenesis. (2014)
• Antihyperglycemic drug Gymnema sylvestre also shows anticancer potentials in human melanoma A375 cells via reactive oxygen species generation and mitochondria-dependent caspase pathway. (2013) Conclusion: Overall results indicate GS to have significant anticancer effect on A375 cells apart from its reported antidiabetic effect, indicating possibility of its palliative use in patients with symptoms of both the diseases.
• Hypolipidaemic Effects of Gymnema sylvestre on High Fat Diet Induced Dyslipidaemia in Wistar Rats (2017)
  Confirms the effective hypolipidamic effects of Gymnema.
• In vitro antimicrobial potential of extracts and phytoconstituents from Gymnema sylvestre R.Br. leaves and their biosafety evaluation. (2017)
• The Effects of Gymnema sylvestre in High-Fat Diet-Induced Metabolic Disorders. (2017) "Our results support the existence of a relationship between the HFD induced insulin resistance, adipose dysfunction and liver steatosis. In conclusion, GS works as a functional dietary supplement with preventative effects against metabolic disorder."
• Suppression of Oral Sweet Taste Sensation with Gymnema sylvestre Affects Postprandial Gastrointestinal Blood Flow and Gastric Emptying in Humans (2017)
• Gymnema sylvestre for Diabetes: From Traditional Herb to Future's Therapeutic. (2017) " The present article discusses the significance of G. sylvestre in diabetes management, the herbal-formulations from the herb together with its standardization and clinical trials on animal models, and why Peroxisome Proliferator Activated Receptor gamma (PPARγ) may serve as a prospective molecular target for Gymnemic acid analogs. Such studies would define the molecular basis of bioactive molecules which would aid in the development of natural product based therapeutics in the treatment of diabetes. "
• Immunomodulatory Effect of Gymnema sylvestre (R.Br.) Leaf Extract: An In Vitro Study in Rat Model. (2015)
• Neuroprotective effects of Gymnema sylvestre on streptozotocin-induced diabetic neuropathy in rats. (2015) "Results: Tthe results demonstrated that the neuroprotective effect of Gs may be associated with the inhibitory effect on the excessive activation of inflammatory molecules and oxidative stress mediators."
• In vivo anti-ulcer, anti-stress, anti-allergic, and functional properties of gymnemic acid isolated from Gymnema sylvestre R Br. (2014) Conclusions: "Conclusions: The aqueous extracts of the leaves of Gymnema sylvestre possess anti ulcerogenic, anti allergic, anti stress properties that may be due to cytoprotective mechanism. These results support the ethno medical uses of the plant in the treatment of gastric ulcer.
• Phytochemical analysis of Gymnema sylvestre and evaluation of its antimicrobial activity. (2013) "The chloroform extracts of aerial and root parts of G. sylvestre exhibited higher antimicrobial activity as compared to diethyl ether and acetone."