Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen
-- (Sept., 2020)
: Ivermectin proposes many potentials effects to treat a range of diseases, with its antimicrobial, antiviral, and anti-cancer properties
as a wonder drug. It is highly effective against many microorganisms including some viruses. In this comprehensive systematic review, antiviral effects of ivermectin
are summarized including in vitro and in vivo studies over the past 50 years. Several studies reported
antiviral effects of ivermectin on RNA viruses such as Zika,
dengue, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and
Respiratory Syndrome, Human immunodeficiency virus type 1, and severe acute respiratory syndrome coronavirus 2. Furthermore, there are some studies showing antiviral
effects of ivermectin against DNA viruses such as Equine herpes type 1, BK polyomavirus, pseudorabies, porcine circovirus 2, and bovine herpesvirus 1
. Ivermectin plays
a role in several biological mechanisms, therefore it could serve as a potential candidate in the treatment of a wide range of viruses including COVID-19 as well as other
types of positive-sense single-stranded RNA viruses. In vivo studies of animal models revealed a broad range of antiviral effects of ivermectin, however, clinical trials
are necessary to appraise the potential efficacy of ivermectin in clinical setting.
A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness
-- (Feb., 2021)
: Ivermectin, a US Food and Drug Administration-approved anti-parasitic agent, was found to
inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in vitro. A randomized, double-blind, placebo-controlled trial was conducted
to determine the rapidity of viral clearance and safety of ivermectin among adult SARS-CoV-2 patients. The trial included 72 hospitalized patients in Dhaka, Bangladesh,
who were assigned to one of three groups: oral ivermectin alone (12 mg once daily for 5 days), oral ivermectin in combination with doxycycline (12 mg ivermectin single dose
and 200 mg doxycycline on day 1, followed by 100 mg every 12 h for the next 4 days), and a placebo control group. Clinical symptoms of fever, cough, and sore throat were
comparable among the three groups. Virological clearance was earlier in the 5-day ivermectin treatment arm when compared to the placebo group (9.7 days vs 12.7 days; p = 0.02),
but this was not the case for the ivermectin + doxycycline arm (11.5 days; p = 0.27). There were no severe adverse drug events recorded in the study. A 5-day course of
ivermectin was found to be safe and effective in treating adult patients with mild COVID-19
. . .
A COVID-19 prophylaxis? Lower incidence associated with prophylactic administration of ivermectin
-- (Jan., 2021)
, Partial: As COVID-19 (coronavirus disease 2019) continues to rapidly spread throughout the world, the incidence varies greatly among
different countries. These differences raise the question whether nations with a lower incidence share any medical commonalities that could be used not only to explain that
lower incidence but also to provide guidance for potential treatments elsewhere. Such a treatment would be particularly valuable if it could be used as a prophylactic
against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) transmission, thereby effectively slowing the spread of the disease while we await the wide availability
of safe and effective vaccines. Here, we show that countries with routine mass drug administration of prophylactic chemotherapy including ivermectin have a significantly
lower incidence of COVID-19. Prophylactic use of ivermectin against parasitic infections is most common in Africa and we hence show that the reported correlation is highly
significant both when compared among African nations as well as in a worldwide context. We surmise that this may be connected to ivermectin's ability to inhibit SARS-CoV-2
replication, which likely leads to lower infection rates. However, other pathways must exist to explain the persistence of such an inhibitory effect after serum levels of
ivermectin have declined.
The association between the use of ivermectin and mortality in patients with COVID-19: a meta-analysis
-- (Mar., 2021)
: The effect of ivermectin on mortality in patients with novel coronavirus disease 2019 (COVID-19) has been investigated in many studies.
We aimed to perform a meta-analysis of randomized controlled trials to investigate the overall effect of ivermectin on the risk of mortality in patients with COVID-19.
(Six randomized controlled trials were included in this analysis with a total of 658 patients who were randomized to receive ivermectin and 597 patients randomized in the
control group who did not receive ivermectin.)
: We observed a preliminary beneficial effect on mortality associated with ivermectin use in patients with COVID-19. . .
Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study
-- (Feb., 2021)
: Ivermectin is one among several potential drugs explored for its therapeutic and preventive role in SARS-CoV-2 infection. The study was
aimed to explore the association between ivermectin prophylaxis and the development of SARS-CoV-2 infection among healthcare workers.
: Two-dose ivermectin prophylaxis at a dose of 300 mcg/kg with a gap of 72 hours was associated with a 73% reduction of SARS-CoV-2
infection among healthcare workers for the following month. Chemoprophylaxis has relevance in the containment of pandemic.
Global trends in clinical studies of ivermecetin in CoVID-19
This 52 page report covers a variety of studies involving ivermectin in the treatment
of CoVid. The results are a mixed bag. On page 39, in the Conclusion
section, the paper
clearly states, "there are many study reports demonstrating that the
administration of a normal dose does indeed show a clinical response. As of the 27th of
February 2021, the results of 42 clinical studies worldwide have undergone meta-analysis
and concluded that ivermectin is effective in the treatment and prevention of COVID-19.
In the UK, a consensus-based recommendation by 75 healthcare professionals
from 17 countries around the world has been carried out and submitted to the WHO to further
encourage the issuance of guidelines for the use of ivermectin in the treatment and
prevention of COVID-19
. However, what precedes this is an arcane discussion
of blood concentration levels, meant to infer that maybe ivermectin isn't so effective
after all. Politics overriding scientific fact. Yet again. This is why
people have lost
faith in scientific studies
, just as they have lost people in these same people,
who knowingly foisted CoVid upon the unsuspecting world.
Physician slams YouTube's 'extremely misguided' decision to pull Senate testimony about COVID treatment
-- In the main column
at left, you'll find a video link to testimony by Dr. Pierre Kory, the president of the Front Line CoVid-19 Critical Care (FLCCC).
In this article, Kory explains what a travesty it was that his Senate testimony about CoVid treatment was taken down by YouTube --
unquestionably to make the trillion dollar vaccine makers happy.
Wikipedia does hit piece on Dr. Pierre Kory, President of the
-- I've been complaining about the tyrannical nature and
truth-destroying tactics of Wikipedia for years
. So it only makes sense that Wikipedia would do a hit-piece on Dr. Kory after his
ivermectin testimony before the U.S. Senate last December (2020). Can't possibly let truth or facts get in the way of the diabolical
goal of fulfilling Bill Gates' vision of a sterilized, human-free planet.
Lectures like this 28 minute segment are becoming more common
where physicians are warning the public about the need for Vitamin D and zinc in the fight against CoVid
and other viral conditions. An excellent presentation
here is made regarding the value of ivermectin around 14:25 -- but this should be viewed within the
context of the rest of the video. Predictably, Facebook's lying "fact checkers" are pooh-poohing
this presentation, so I don't expect it to stay up for long
Ivermectin has a number of potentially serious drug-drug interactions.
Please check for potential drug interaction at
Ivermectin Drug Interactions - Drugs.com
The most important drug interactions occur with cyclosporin, tacrolimus, anti-retroviral drugs, and certain anti-fungal drugs.
Due to the possible drug interaction between quercetin and ivermectin (may increase ivermectin levels),
these drugs should not be taken simultaneously (i.e. should be staggered morning and night). Ivermectin is also lipophilic and therefore,
bioavailability is maximised on a full stomach; or best to be taken with meal.